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KMID : 1211620100050030455
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Journal of the Korean Society of Physical Medicine
2010 Volume.5 No. 3 p.455 ~ p.465
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Effects of Motor Skill Learning on Balance and Coordination in Excitoxicity Induced Cerebellar Injury Model of Rat
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Kim Gi-Do
Min Kyung-Ok
Sim Jae-Hwan
Jeong Jae-Young
Kim Young-Eok
Kim Kyung-Yoon
Kim Gye-Yeop
Sim Ki-Cheol
Kim Eun-Jung
Nam Ki-Won
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Abstract
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Purpose: This study is intended to examine the motor skill learning on balance and coordination in the cerebellar injured rats by 3AP.
Methods: This study selected 60 Sprague-Dawley rats of 8 weeks. Experiment groups were divided into four groups and assigned 15 rats to each group. Group I was a normal control group(induced by saline); Group II was a experimental control group(cerebellar injured by 3AP); Group III was a group of motor skill learning after cerebellar injured by 3AP; Group IV was a group of treadmill exercise after cerebellar injured by 3AP. In each group, motor performance test, histologic observations, synaptophysin expression and electron microscopy observation were analyzed.
Results: In motor performance test, the outcome of group II was significantly lower than the group III, IV(especially group III)(p<.001). In histological finding, the experimental groups were destroy of dendrities and nucleus of cerebellar neurons. Group III, IV were decreased in degeneration of cerebellar neurons(especially group III). In immunohistochemistric response of synaptophysin in cerebellar cortex, experimental groups were decreased than group I. Group III’s expression of synaptophysin was more increased than group II, IV. In electron microscopy finding, the experimental groups were degenerated of Purkinje cell.
Conclusion:These result suggest that improved motor performance by motor skill learning after harmaline induced is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity.
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KEYWORD
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Cerebellar, 3AP, Motor performance, Motor skill learning, Synaptic plasticity
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